Research interests

• Experimental and Theoretical Biophysics,
• Fluorescence Microscopy and Spectroscopy,
• Function and Lateral Organization of Biomembranes,
• Single Molecule Fluorescence Photophysics,
• Green Fluorescent Proteins.

Publications

• Blake RD, Hess ST. 1992. The pattern of substitution mutation in different nearest-neighbor environments of the human genome. Comput Chem 16:165-170
• Blake RD, Hess ST, Nicholson-Tuell J. 1992. The influence of nearest neighbors on the rate and pattern of spontaneous point mutations. J Mol Evol 34:189-200
• Marx KA, Hess ST, Blake RD. 1993. Characteristics of the large (dA)(dT) homopolymer tracts in D discoideum gene flanking and intron sequences. J Biomol Struct Dyn 11:57-66
• Hess ST, Blake JD, Blake RD. 1994. Wide variations in neighbor-dependent substitution rates. J Mol Biol 236:1022-1033
• Marx KA, Hess ST, Blake RD. 1994. Alignment of (dA) (dT) homopolymer tracts in gene flanking sequences suggests nucleosomal periodicity in D Discoideum DNA. J Biomol Struct Dyn 12:235-246
• McCambridge JD, Rizzo ND, Hess ST, Wang JQ, Ling XS, Prober DE. 1997. Pinning and vortex lattice structure in NbTi alloy multilayers. IEEE Trans Appl Supercon 7:1134-1137
• Albota M, Beljonne D, Brédas J-L, Ehrlich J, Fu J-Y, Heikal A, Hess S, Kogej T, Levin M, Marder S, McCord-Maughon D, Perry J, Röckel H, Rumi M, Subramaniam G, Webb W, Wu X-L, Xu C. 1998. Design of organic molecules with large two-photon absorption cross sections. Science 281:1653-1656
• Heikal AA, Hess ST, Baird GS, Tsien RY, Webb WW. 2000. Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: Coral red (dsRed) and yellow (Citrine). Proc Natl Acad Sci USA 97:11996-12001. See also correction in same volume, p:14831
• Heikal AA, Hess ST, Webb WW. 2001. Multiphoton molecular spectroscopy and excited-state dynamics of enhanced green fluorescent protein (EGFP): acid-base specificity. Chem Phys 274:37-55
• Hess ST, Webb WW. 2002. Focal volume optics and experimental artifacts in confocal fluorescence correlation spectroscopy. Biophys J 83:2300-2317
• Hess ST, Huang S, Heikal AA, Webb WW. 2002. Biological and chemical applications of fluorescence correlation spectroscopy. Biochemistry 41:697-705
• Heikal AA, Hess ST, Sheets ED, Webb WW. 2002. Mutation-photophysics Relationship in Intrinsically Fluorescent Proteins. In: Femtochemistry and Femtobiology: Ultrafast Dynamics in Molecular Science. Douhal A, Santamaria J (Eds). World Scientific Publishing Co Pte Ltd, Singapore
• Baumgart T, Hess ST, Webb WW. 2003. Imaging Coexisting Fluid Domains in Biomembrane Models Coupling Curvature and Line Tension. Nature 425:821-824
• Hess ST, Sheets ED, Wagenknecht-Wiesner A, Heikal AA. 2003. Quantitative analysis of the fluorescence properties of intrinsically fluorescent proteins in living cells. Biophys J 85:2566-2580
• Hess ST, Heikal AA, Webb WW. 2004. Fluorescence photoconversion kinetics in novel green fluorescent protein pH sensors (pHluorins). J Phys Chem B 108:10138-10148
• Zimmerberg J, Kumar M, Verma A, Farrington J, Roth M, Kenworthy A, Hess ST. 2004. Studying spatial distributions of influenza hemagglutinin on the plasma membrane of fibroblasts: A work in progress. Macromolecular Symposia 219:17-23
• Hess ST, Kumar M, Verma A, Farrington J, Kenworthy A, Zimmerberg J. 2005. Quantitative electron microscopy and fluorescence spectroscopy of the membrane distribution of influenza hemagglutinin. J Cell Bio 169:965-976
• Mukesh K, Hess S, Verma A, Farrington J, Kenworthy A, Roth M, Zimmerberg J. 2005. Lipid-protein interactions mediate influenza viral infection and membrane fusion. (in prep)
• Hess ST, Heikal AA, Webb WW. 2005. Comparative Studies of Molecular Dynamics and Spectroscopy of Mutated Green Fluorescent Proteins. (in prep)

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