Recent advances in combinatorial chemistry and genetic engineering have created an intensive demand to analyze large numbers but small amount of compounds quickly. To provide a solution, MISL lab presents the first generation prototype of a modular, microfabricated separation and detection microsystem capable of parallel chemical separation and analysis of analytes. The two primary modules of the microsystem are: 1) a capillary electrophoresis (CE) module for sample separation, and 2) an electrochemiluminescence (ECL) module for optical detection. Additionally, the two modules are equipped with fluidic multi-interconnections to interface the modules to each other and/or the external world. Detail of the device will soon be published in Biomedical Microdevices.
The integration of three different types of modules. The module on the right is an external interconnect module with tubing to interface with external reagents, etc. The module in the center is an ECL detection module with electrodes. The modules on the right and left show microbore tubing interconnections.
Cross sectional perspective the ECL detection module.
A photo of two modules interfaced via the tubing interconnects.
A photo of the cross section of the interface of polysiloxane adhesion bonding.
Photo of two ECL measurements of the prototype.
Photo of ECL measurements setup.
The electrophoresis separation of bromophenol blue and xylene cyanol in agarose and TEA buffer.
The Micro Instruments & Systems Laboratory
part of the Laboratory for Surface Science & Technology
A Member of the University of Maine System
